Multivariate analysis further identified cirrhosis (p = 0.035, HR = 4.545, CI = 1.115–18.522), tumor size (p = 0.023, HR = 1.635, CI = 1.070–2.497), CLIP stage (p = 0.001, HR = 2.175, CI = 1.388–3.409), and high SERPING1 levels (p = 0.033, HR = 0.640, CI = 0.425–0.964) as independent factors associated with improved overall survival (Table 2). This evidence concerns the gene SERPING1 and Cirrhosis.