Pyruvate kinase M (PKM), which can be alternatively spliced into two isoforms, PKM1 and PKM2, acts as a key glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate to pyruvate and mediates the Warburg effect in cancers.[29, 30] Additionally, PKM2 acts as a prominent isoform of pyruvate kinase that functions in endothelial cells and plays an essential role in endothelial cell proliferation.[31] Moreover, PKM2 structurally exists as tetramer, dimer, or monomer. The gene discussed is PKM; the disease is cancer.