PKM and cancer: PKM2 is an important isoform of pyruvate kinase that functions as the ultimate rate‐limiting enzyme in glycolysis.[54, 55] Generally, PKM2 is highly expressed in tissues faced with increased anabolic demands, with particular reference to demands from proliferating cells, such as cancer cells.[30, 56, 57] Excessively activated PKM2 induces lactate accumulation, disrupts glucose metabolism, and impairs homeostasis.