According to the Bonferroni significance test (P < 5e-08), MR analysis demonstrated a causal relationship between 11 proteins and hyperlipidemia (Table 1; Figure 2C), including angiopoietin-related protein 3 (ANGPTL3), apolipoprotein A-V (APOA5), apolipoprotein C-III (APOC3), apolipoprotein B (APOB)-100, basal cell adhesion molecule (BCAM), glucokinase regulatory protein (GCKR), kallikrein-1 (KLK1), neurocan core protein (NCAN), protein convertase subtilisin/kexin type 9 (PCSK9), transgelin (TAGLN), and T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4). The gene discussed is APOA5; the disease is hyperlipidemia.