Specifically, increased levels of GCKR (odds ratio [OR] = 0.42, 95% confidence interval [CI], 0.37–0.47; P = 3.64e-45) and TIMD4 (OR = 0.60, 95% CI, 0.50–0.72; P = 4.43e-08) decreased the risk of hyperlipidemia. This evidence concerns the gene GCKR and hyperlipidemia.