Further examples of anti-tumor activities of naringeninare available, among them we can mention apoptotic induction in HTP-1 leukemia cellline by disruption in mitochondrial membrane potential, decreasing AKT activity, andtriggering caspase cascade; or the same consequence in HepG2 (a delegacy of livercancer) cell line by up-regulating the ratio of Bax/Bcl2 [5][6][7][8][9][10]. Here, BCL2 is linked to leukemia.