In the univariate analysis, factors associated with inferior OS included age >60 years, ECOG performance status ≥ 2, anemia, NLR2 < 4.635, elevated β2M, elevated LDH, Alb < 3.5 g/dL, eosinophil < 0.02, DBIL > 6.8, hepatomegaly, serous cavity effusion, SUVmax > 12, Ki-67 >45%, and CD20+ and EBV-DNA ≥ 500 copies/mL (Table 1). This evidence concerns the gene B2M and anemia.