Ki67 significantly increased in CD8+ (Supplementary Figure S3D) and CD4+ T cells (Supplementary Figure S3F) in both the spleen and the tumor site, indicating that CXCL10-Fc also induced these cells in the periphery, but the most significant result is at the tumor site where the relative tumor-specific CD8+ T cells are comparatively high (Supplementary Figure S3E). The gene discussed is CD4; the disease is neoplasm.