The importance of CXCL10 produced by the cancer cells has been emphasized by a recent study comparing response to anti-PD-1 using colon cancer cells that are CXCL10high (CT26), and CXCL10low (Colon 26), showing that only the first respond to anti-PD-1 treatment (46). The gene discussed is CXCL10; the disease is malignant colon neoplasm.