Further, erythropoiesis-related genes are upregulated in PBMCs of patients with systemic-onset juvenile idiopathic arthritis (SoJIA) (184), while active SoJIA-driven CECs co-cultured with healthy donor monocytes suppress IL-1β, IL-6, and IL-8 secretion. The gene discussed is IL6; the disease is systemic-onset juvenile idiopathic arthritis.