GCSAM and diffuse large B-cell lymphoma: A series of investigations have first delineated an HGAL-dependent pathway via which HGAL’s consensus PBM motif (15, 32) recruits PDZ-RhoGEF, heightens RhoA activity, and leads to cytoskeletal component restructuring in DLBCL and Burkitt lymphoma cell lines (4, 5, 8, 15, 16, 32, 50–55) (see Figure 1C, right column).