In DLBCL and Burkitt lymphoma cell lines (with endogenous HGAL KO’s) wt-HGAL expression reinforced dense cSMAC formation [induced by anti-human IgM (FAB′)2] with HGAL co-localizing with BCR’s and GRB2. The gene discussed is GCSAM; the disease is diffuse large B-cell lymphoma.