GCSAM and diffuse large B-cell lymphoma: HGAL’s pY128 and pY148 sites approximate ITAM motifs (8, 13, 38, 39), and co-immunoprecipitation experiments using epitope-tagged HGAL truncation and pY->F constructs (expressed together with SYK in DLBCL VAL cells) have demonstrated SYK binding to HGAL via HGAL’s paired C-terminal pY motifs (13).