On day 21 after transplantation (11-12 days after DT injection), the increased frequencies of Tim3+PD-1+ and Foxp3+ regulatory T cells by myeloma transplantation were cancelled by the loss of cDC1s (Figures 4A, B), whereas those of total CD8, Tim3-PD-1+ CD8 T, and total CD4 T cells in the bone marrow were comparable. The gene discussed is CD4; the disease is plasma cell myeloma.