Aberrant cell cycle reentry or cell cycle arrest was reflected by increased expression levels of Ki67, proliferating cell nuclear antigen, cyclin E and cyclin D1 in the muscle samples from the patients with inclusion body myositis and polymyositis, as well as the brain samples from Alzheimer’s disease patients (Kwon et al., 2014). This evidence concerns the gene MKI67 and early-onset autosomal dominant Alzheimer disease.