Distribution of the SIRT1 genotypes (rs3758391 T > C) was in Hardy‐Weinberg equilibrium in all T2DM patients (χ2 = 2.33, p > 0.1), in T2DM patients without complication (χ2 = 2.04, p > 0.1), in T2DM patients with neuropathy (χ2 = 0.92, p > 0.1) and in T2DM patients with retinopathy (χ2 = 0.08, p > 0.1). Here, SIRT1 is linked to type 2 diabetes mellitus.