ADIPOQ and obesity due to melanocortin 4 receptor deficiency: However, upon analyzing correlations among nondiabetic individuals with or without obesity (NOND-OND), diabetic individuals with or without obesity (NOD-OD), and obese diabetics (NOND-OD), the findings align with those observed in gerbils, only negative correlations between adiponectin and leptin, and positive correlations between adiponectin and HDL.