For the proper categorization of ependymal tumors, we still require ZFTA and YAP fusions, and for the adequate classification of medulloblastoma, although we have N-MYC and C-MYC (by FISH), we are still lacking DNA methylation analysis, as well as immunohistochemistry for YAP1 and GAB1 (1). The gene discussed is MYC; the disease is medulloblastoma.