As for the role played by PTK7, it has been shown that PTK7 could enhance cancer cell adhesion by stabilizing NDRG1, and the PTK7-NDRG1 axis is recognized as a key factor in the development of resistance to AZD9291 (osimertinib) in lung adenocarcinoma cells (80). Here, PTK7 is linked to lung adenocarcinoma.