Similarly, in a colon cancer (HT-29) xenograft mouse model, it was reported that PS caused a decrease in the expression of the antiapoptotic Bcl-2 gene at the mRNA level and increased the expression of the proapoptotic Bax, Bak, Bad, and Bid genes (Priego et al., 2008). The gene discussed is BCL2; the disease is malignant colon neoplasm.