CYCS and cancer: Additionally, PS treatment induced apoptosis in bladder (T24 and T24R) cancer cell lines by decreasing the expression of Bcl-2 and Bcl-xl, increasing Casp-3, and keeping Bax and Bad unchanged.28 In addition, PS treatment was observed to induce apoptosis in gastric cancer (AGS) cells by promoting an increase in the expression of Bad, Bax, cytochrome c, and Casp-3- and −9 and decreasing mitochondrial transmembrane potential (Liu et al., 2020).