Similarly, PS treatment has been shown to promote a concentration-dependent increase in Casp-3 and Bax but decrease in Bcl-2 ratio in pancreatic, breast, prostate, and endometrial cancer cell lines (Chakraborty et al., 2010; Wen et al., 2017; Hsu et al., 2020). This evidence concerns the gene CASP3 and endometrial cancer.