Similarly, in a colon cancer (HT-29) xenograft mouse model, it was reported that PS caused a decrease in the expression of the antiapoptotic Bcl-2 gene at the mRNA level and increased the expression of the proapoptotic Bax, Bak, Bad, and Bid genes (Priego et al., 2008). This evidence concerns the gene BID and malignant colon neoplasm.