Recently, Fu et al. developed the firstCL platform for FAPα in vitro assay in plasmaand its in vivo imaging in tumor cells of mice (Figure 2B).63 The developed probes were based on using glycine-prolinedipeptide ligand as FAPα-specific moiety in the adamantylidene-dioxetanemolecule. The gene discussed is FAP; the disease is neoplasm.