IL-2, IL-1β, IFN-γ, IL-6, TNF-α, and IL-8 is a pro-inflammatory cytokine associated with inflammatory bowel disease, and the pro-inflammatory cytokine response is a critical pathophysiological factor in the acceleration of the occurrence and development of UC (Ungaro et al., 2017). The gene discussed is IL1B; the disease is inflammatory bowel disease.