To examine whether ZFP41 regulates the repression effects by inhibiting the Snail expression in HCC cells, we detected the protein levels of Snail and EMT pathway‐related targets in Hep3B cells overexpressing ZFP41 and MHCC‐97H cells with ZFP41 knockdown were detected. This evidence concerns the gene SNAI1 and hepatocellular carcinoma.