It has been found that YTHDF3 accelerates aerobic glycolysis and development of HCC by impeding PFKL mRNA degradation via m6A modification, and the PFKL protein augments the expression of YTHDF3 protein by inhibiting EFTUD2‐mediated ubiquitination of YTHDF3 protein, thus creating a positive loop between YTHDF3 and PFKL.10 The gene discussed is YTHDF3; the disease is hepatocellular carcinoma.