CREB1 and neoplasm: The miRNA-target interaction network showed that several tumor suppressor miRNAs identified in our study, such as hsa-miR-146a-5p, hsa-miR-378a-3p, hsa-miR-29a-3p and hsa-miR-185-5p, target multiple critical genes, including MYC, CREB1, TIMP3, CCNE1, and TGFB1, which were also shown to be involved in WT pathogenesis.