FOXO3 and Nephroblastoma: FOXO3a, a tumor suppressor gene, has been observed to inhibit growth and invasion of nephroblastoma cells by disrupting the Wnt/β-catenin signaling pathway (Geng et al., 2022).The MAPK pathway has been found to be involved kidney growth, branching of the Ureteric Bud, and nephric duct connection to the cloaca.