FOXO3a, a tumor suppressor gene, has been observed to inhibit growth and invasion of nephroblastoma cells by disrupting the Wnt/β-catenin signaling pathway (Geng et al., 2022).The MAPK pathway has been found to be involved kidney growth, branching of the Ureteric Bud, and nephric duct connection to the cloaca. Here, FOXO3 is linked to Wilms tumor.