Importantly, itsexcretionin the kidney is rapid (∼87% excretion within 6 h), and weperformed the first noninvasive fluorescence imaging of the urinarytract from intact mouse tissue (Figure 7a).152 Gu et al.153 synthesized a targeting peptide H1 with highaffinity for epidermal growth factor receptor (EGFR) and further coupledit with a near-infrared fluorescent molecule, MPA, to synthesize aprobe, H1-MPA, which has a high tumor uptake rate and signal-to-noiseratio and can be used to locate tumor boundaries (Figure 7b). The gene discussed is EGFR; the disease is neoplasm.