The etiopathogenesis of NEC remains unclear but an immature intestinal barrier, altered microbiota, intestinal immaturity [7], enteral feeding with formula milk [8], bacterial colonization, hypoxic-ischemic damage, and aberrant toll-like receptor 4 (TLR4)-mediated intestinal inflammatory response are contributing factors [9]. This evidence concerns the gene TLR4 and necrotizing enterocolitis.