BCL10 (3.84-fold), TRADD (2.71-fold), CYCS (2.51-fold), DIABLO (2.43-fold), BAD (2.36-fold), BID (2.17-fold), TNFSF8 (2.13-fold), TNFSF10 (2.11-fold), BAX (2.03-fold), and FAS (2.01-fold) were also proapoptotic genes highly upregulated in response to UA treatment in A-375 melanoma cells (Figure 2c). This evidence concerns the gene TNFSF8 and melanoma.