The following relevant keywords were incorporated into the search strategy: “Inclisiran.” “Leqvio,” “PCSK9 inhibitors,” “Atherosclerosis,” “Atherosclerotic cardiovascular disease,” “Safety,” “Complications,” and “Efficacy.” A pair of impartial evaluators methodically examined the search outcomes, identified relevant research, collected pertinent information, and evaluated the caliber of the included studies by utilizing suitable assessment instruments. The gene discussed is PCSK9; the disease is atherosclerosis.