CD44 and neoplasm: Furthermore, Friedman’s ANOVA analysis applied for each surface marker individually showed a statistically significant difference between the three moments in time (CD44 - p = 0.0003, CD 133 - p = 0.0067, CD326/EpCAM - p = 0.0002, and SSEA4 - p = 0.0103, respectively): their expression lowered after surgical removal of the tumor, but it was slowly increasing three months later.