FOXC2 and Distichiasis: Systemic dysregulation of FOXC2 has been found to promote defects in lymphatic vasculature and hereditary lymphedema-distichiasis syndrome, which presents as distichiasis (double rows of eyelashes) and lower-limb lymphedema that develops in adolescence (Tavian et al., 2016; Fang et al., 2000; Erickson et al., 2001).