RS1 and cyst: Figure 1 demonstrates typical ERG waveforms for this XLRS model at 2 and 6 months of age under light-adapted (5 Hz flicker) metrics (Figure 1D). In summary, features of the Rs1-KO mouse model resemble the clinical course in humans, including cyst formation, ONL thinning, and diminished electrical activity of retinal photoreceptors and bipolar cells observable on ERG. The phenotypes observed mirror those reported by Sieving et al. (14).