SLC40A1 and Alzheimer disease: Moreover, the overexpression of Fpn, responsible for storing and regulating iron elements, playing a crucial role in the storage, release, and regulation of iron within cells (Jakaria et al., 2021), has been shown to partially improve memory impairment and reduce ferroptosis in mouse models of AD, providing further evidence for the crucial role of Fpn in the disease (Jakaria et al., 2021; Wang F. et al., 2022) (see Figure 2).