BCL2 and neoplasm: Proapoptotic B-cell lymphoma-2 (BCL-2) family members, caspase activation, cleavage of hundreds of caspase substrates (e. g. intracranial atherosclerotic disease (ICAD), Poly ADP-ribose polymerase (PARP)), phosphatidylserine exposure, Mitochondrial Membrane Potential (△ψm) dissipation, Manganese-Based Tumor Immunotherapy (MOMP) and ROS production.