SMO and infection: Toward this aim, we investigated the impact of Smo on Budesonide-induced MBP expression by utilizing two isogenic cell lines, the Oli-neuMshSmo and the Oli-neuMshCTL, previously created by infection with Lentivirus particles carrying, respectively, the pLKO.1 vector expressing Smo shRNA (shSmo) and a pLKO.1 vector expressing a control shRNA (shCTL) (Del Giovane et al., 2022).