MAPT and early-onset autosomal dominant Alzheimer disease: Given a multifactorial disorder, Alzheimer's disease (AD) pathogenesis involves dysregulation in diverse biochemical processes (Dorszewska et al., 2016; Koutsodendris et al., 2022; López‐Ortiz et al., 2021), including abnormal amyloid‐β (Aβ) production and impaired Aβ clearance, tau hyperphosphorylation, insufficiency in brain glucose utilisation, mitochondrial dysfunction, lipid dyshomeostasis, oxidative stress, neuroinflammation and neurotransmitter dyshomeostasis (Toledo et al., 2017; Wang et al., 2021; Wilkins & Trushina, 2018).