We previously reported that hepatocyte E4bp4 deficiency protects mice from hepatocyte injury or liver steatosis following 10‐week HFLMCD diet or 12‐week HFD, respectively.[34, 35] In response to the HFLMCD diet, loss of hepatocyte E4bp4 could offer protection by promoting sustained activation of the AMPK pathway.[34] In the case of HFD, E4bp4‐LKO mice were most likely protected via the downregulation of hepatic Fsp27β and lipid droplet biogenesis.[35] Interestingly, we did not observe similar responses in E4bp4‐LKO mice on the NASH diet. This evidence concerns the gene NFIL3 and metabolic dysfunction-associated steatohepatitis.