NFIL3 and metabolic dysfunction-associated steatohepatitis: To this end, we first generated hepatic overexpression of the E4BP4 model by injecting AAV8‐TBG‐E4bp4 into WT mice and feeding mice NASH diet for 5 weeks before injecting mice with either Ad‐shLacZ or Ad‐shOpn and continuing NASH diet for two additional weeks.