NFIL3 and metabolic dysfunction-associated steatohepatitis: In this study, we show that upon chronic intake of a diet enriched in fructose, cholesterol, and saturated fat (NASH diet), WT mice develop the whole spectrum of MASH, including liver steatosis, inflammation, and fibrosis, whereas mice with hepatocyte E4bp4 deficiency are protected from fibrosis and inflammation despite a similar degree of liver steatosis.