We previously reported that E4BP4 interacts with nuclear SREBP‐1C in response to insulin or feeding to stimulate de novo lipogenesis.[32] We also discovered that E4BP4 is also required for CREBH‐mediated activation of Fsp27β in the context of HFD feeding.[35] Here we discovered that E4BP4 interacts with YAP to promote the OPN expression in response to NASH feeding. The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.