Deletion of Yap in HSCs reverses liver fibrosis during NASH diet.[65, 66] Hepatocyte‐specific Yap knockout mice are protected from insulin resistance‐induced liver fibrosis.[67] Here we demonstrate that hepatocyte E4BP4 interacts with YAP and promotes its protein stability in hepatocytes and the liver. The gene discussed is NFIL3; the disease is Insulin resistance.