APOE and atherosclerosis: We generated myeloid-specific Hif-1α KO mice by crossing mice expressing Cre-recombinase under hMRP8 myeloid-specific promoter with mice having Hif-1α floxed mice (hMRP8Cre+; Hif-1αfl/fl) and further crossed them to ApoE null background (hMRP8Cre+; Hif-1αfl/fl; ApoE−/−; hereafter denoted as myeloid-specific Hif-1α KO mice) to initially examine a role of HIF-1α in myeloid cells in atherosclerosis.