On the basis of the results of the gene enrichment analysis, the PI3K/mTOR/AKT signaling pathway is activated in uLMS via different mechanisms, including the amplification of mTOR, RICTOR, AKT, or insulin-like growth factor 1, as well as the loss of tumor suppressors such as PTEN [14, 55]. This evidence concerns the gene AKT1 and neoplasm.