While patients with ATTRwt predominantly present with cardiac phenotypes (i.e., TTR cardiomyopathy [ATTR-CM]), patients with ATTRv present with various types of phenotypes that can be predominantly neuropathic (i.e., TTR familial amyloid polyneuropathy [ATTR-PN]), cardiac (i.e., ATTR-CM) or mixed [2]. The gene discussed is TTR; the disease is familial amyloid neuropathy.