To confirm the role of G6PD in the METTL3-mediated OXA susceptibility of HCC cells, we performed ectopic expression of G6PD in METTL3-silenced cells and observed a rescue of METTL3-silenced induced OXA susceptibility in both CCK-8 and colony formation assays (Fig. 2I–K). This evidence concerns the gene METTL3 and hepatocellular carcinoma.