For example, METTL3-mediated stabilization of USP13 RNA has been shown to promote autophagy and imatinib resistance in gastrointestinal stromal tumors [34], while in HCC, METTL3 has been reported to regulate cancer stem cell properties and contribute to lenvatinib resistance via FZD10 [35]. This evidence concerns the gene USP13 and hepatocellular carcinoma.