ELN and melanoma: Amanpreet Kaur et al. reported that the aged ECM promotes melanoma cell metastasis and inhibits T cell migration.49 Ishier Raote et al. found that regulating ECM components may have therapeutic effects in wound healing and fibrosis processes.50 We showed that AMSC-EV and HUMSC-EV significantly increased dermal collagen and elastin levels in photoaged skin.