The ZNF521 gene is critical for MLLr AMLs25,26, and the MLL::AF10, MLL::AFDN and MLL::AF9 oncoprotein scores on the ZNF521 locus are positively correlated with the overall oncoprotein scores in the AML samples (Fig. 4e,f). This evidence concerns the gene MLLT3 and acute myeloid leukemia.