KMT2A and leukemia: We used AutoCUT&RUN20 to profile MLL-oncoprotein binding sites in 36 MLLr leukemia samples, including 4 cells lines, 14 infant leukemias and 18 leukemias from pediatric or adult patients that are representative of the major lineage subtypes and the most common oncoproteins found in MLLr leukemias (Fig. 1a, Supplementary Fig. 1a–c, Supplementary Data 1).