Compared with CIH group, Dusp1 knockdown significantly enhanced the phosphorylation of Erk1/2 and Drp1 (Fig. 8B), exacerbating remodeling, muscularization of distal pulmonary arteries, and pronounced pulmonary fibrosis around the pulmonary arterial tissues (Fig. 8C, G, H). The gene discussed is MAPK3; the disease is pulmonary fibrosis.