Compared with CIH group, Dusp1 knockdown significantly enhanced the phosphorylation of Erk1/2 and Drp1 (Fig. 8B), exacerbating remodeling, muscularization of distal pulmonary arteries, and pronounced pulmonary fibrosis around the pulmonary arterial tissues (Fig. 8C, G, H). Here, DNM1L is linked to pulmonary fibrosis.