GAD1 and type 1 diabetes mellitus: For T1D-derived GAD clonotypes, the range of frequencies is comparable to those of HD-derived and CMV clonotypes; however, the convergence levels are much higher (compare red dots to blue and grey ones in Fig. 8g, h), indicating that the T cell clones expanded in CM in T1D were both easy to be generated in the thymus and prone to be expanded in the periphery, suggesting the possibility that convergent clonotypes in T1D are more easily expandable after antigen encounter.