Of these, G6PC2 of the glucose-6-phosphatase (G6Pase) catalytic enzyme system is downregulated and is interestingly a major target for cell-mediated autoimmunity in diabetes63, yet G6PC2 is mostly known to be expressed in pancreatic islets and its role in the DRG needs to be further studied. This evidence concerns the gene G6PC2 and Autoimmunity.