MAP2K7 and neoplasm: The MAPK pathway plays a crucial role in the proliferation and survival of tumor cells, consisting of RAS (rat sarcoma virus (RAS), rapidly accelerated fibrosarcoma (RAF), mitogen-activated protein kinase kinase (MEK), and extracellular signal-regulated kinases (ERK), which transmit proliferation and cytoplasmic signals from cell surface receptors to the cell nucleus.