For example, Zheng et al. demonstrated that urolithin A (UA) treatment activates PINK1/Parkin-driven mitophagy in tumor-associated macrophages, resulting in a decrease in stimulator of interferon genes (STING)-mediated inflammation and subsequently a reduction in the release of inflammatory factors such as IL-6 in the TME [103]. This evidence concerns the gene STING1 and neoplasm.