HMGB1 and neoplasm: Interestingly, during mitophagy, the authors observed the release of several endogenous DAMPs (such as ATP and HMGB1) and the expression of calreticulin (CRT) on the surface of 4T1 cells, which led to increased tumor-infiltrating lymphocytes (TILs) and elicits robust immune activation within the tumor microenvironment (TME) [107].