In preclinical studies where the uPAR-PET binding peptide, AE105, used in our PET tracer was labeled with fluorophores, it has been shown that in an orthotopic GBM model that the tracer seems to reach the diffuse cancer cells outside the bulk tumor (unpublished data) and in a BBB spheroid model, a clear indications of BBB crossing was found [36]. Here, PLAUR is linked to neoplasm.