BCR and chronic myelogenous leukemia, BCR-ABL1 positive: 2013). With the emergence of advanced sequencing technology, specific driver genes, including oncogenes, tumor suppressor genes and DNA repair genes, have been found to be responsible for carcinogenesis. For example, tumor suppressor genes APC, TP53 and oncogene KRAS are the most commonly mutated driver genes in colorectal cancer (Morin et al. 1997; Fearon 2011; Tomasetti et al. 2015), and fusion gene BCR-ABL is found to cause chronic myeloid leukemia (Deininger et al. 2000).