Among the TFs which bind with SWI/SNF subunits in leukaemia cells is pioneer factor PU.1, which primarily binds to its targets independently of the SWI/SNF and subsequently recruits SWI/SNF to enhance chromatin accessibility for other critical AML regulatory factors, such as RUNX1, LMO2 and MEIS1 [62] (figure 3). This evidence concerns the gene SMARCA1 and leukemia.