An improved perspective of the MYC–SNF5 interaction indicates that SNF5 deletion in tumours, particularly in malignant rhabdoid tumour (MRT), leads to uncontrolled MYC activity with the help of SNF5 depleted SWI/SNF complex and describes how MYC target genes are upregulated in SNF5-deleted cancers. This evidence concerns the gene SMARCB1 and cancer.