When the SN Dif-EOL1 and the C + P regimen were added concomitantly to the M14K or ZL34 mesothelioma cells, the anti-apoptotic effect of the eosinophilic supernatant was lost, as reflected by the percentage of Annexin V+ PI+/− cells (Supplementary Fig. S4a-b). The gene discussed is ANXA5; the disease is mesothelioma.