During the fungal infection CLRs include Dectin-1 (also known as CLEC7A), Dectin-2 and Mincle expressed on macrophages, dendritic cells or neutrophils play a pivotal role in the recognition of fungal cell wall components such as β-glucans, a-mannans, and glycolipids [5–7]. Here, LARS1 is linked to fungal infectious disease.