Using a lineage marking system, one study found a subset of EGCs to differentiate into enteric neurons 3 months after the direct chemical ablation of the myenteric plexus.21 Another group demonstrated that chemical colitis triggered robust neurogenesis by Sox2+ and Plp1+ EGCs22 and that this response was dependent on serotonin signaling.23 Although it is now well recognized that EGCs can become enteric neurons under the right conditions, the exact nature and location of this neurogenic glial subtype is unknown. The gene discussed is SOX2; the disease is colitis.