Furthermore, silencing MALAT1 has been observed to increase the expression of microRNA-184 (miR-184) when activating Caspase3 activity, as well as inhibiting the expression of Bcl-2 and increasing the expression of Bax proteins; this indicates that miR-184 is the target miRNA of Lnc-RNA MALAT1 and MALAT1 induces CRC cell progression via inhibition of miR-184 [64]. This evidence concerns the gene BAX and colorectal carcinoma.