The gene-based MAGMA analyses for binary measures of neuropathic pain vs no pain within the participants with diabetes revealed 2 significantly associated genes: Lim homeobox 8 (LHX8, P = 2.26 × 10−7) and transcription factor 7 like 2 (TCF7L2, P = 7.80 × 10−7) with a genome-wide significance threshold of P = 2.655 × 10−6 for 18,829 mapped protein coding genes (Fig. 3). The gene discussed is TCF7L2; the disease is diabetes mellitus.