LHX8 and osteoarthritis: LHX8 was found to be associated with educational attainment (P = 9.75 × 10−11), educational qualifications (P = 5.88 × 10−7), and osteoarthritis (P = 9.06 × 10−6), and the KCNT2 and NOS1AP genes displayed associations with 34 diverse traits after Bonferroni correction, encompassing ophthalmological, cellular, psychiatric, immunological, cardiovascular, and metabolic domains (refer to Supplementary Tables 6 and 7, available at http://links.lww.com/PAIN/C169).