NOS1AP and neuropathy: This gene has not previously been linked to human pain41; however, preclinical studies have implicated KCNT2 in neuropathic pain.60 When using neuropathy severity as a covariate, we found a significant association between the locus nitric oxide synthase-1 adaptor protein (NOS1AP, lead SNP rs10919166) and painful diabetic neuropathy.