GFRA2 and Sciatica: Those performed in diabetic populations have found suggestive variants for neuropathic pain including one near GFRA2 (encoding GDNF family receptor alpha 2).42,43 A meta-analysis of GWASs of sciatica identified a genome-wide significant locus near NFIB (nuclear factor I B).33 A recent meta-analysis of GWASs of neuropathic pain revealed a genome-wide significant locus at chromosome 12q23.1, which mapped to SLC25A3 encoding a mitochondrial phosphate carrier.65