Some studies found a higher frequency of rare SCN9a variants in painful compared with painless diabetic neuropathy (including variants with gain of function characteristics).10,34 A recent study by the PROPANE group reported potentially pathogenic variants in SCN9A in a similar proportion in painful and painless diabetic neuropathy (3.0% and 2.9% of participants, respectively), although no formal gene burden analysis was conducted.1 These discrepancies may be related to differences in both case definition and selection, variant filtering, and analytic tools deployed. The gene discussed is SCN9A; the disease is diabetic neuropathy.