Han et al. (Han et al. 2021) identified four molecular subtypes of PCa by using bulk and single-cell RNA sequencing techniques, including luminal A (adipogenic/AR-active/PSA-high ), luminal S (secretory/PAP-high), AVPC-I (immune-infiltrative) and AVPC-M (Myc-active). Here, MYC is linked to posterior cortical atrophy.