AR and posterior cortical atrophy: An analysis of ScRNA-seq carried out on primary PCa and CRPC/mCRPC samples also revealed that pre-existing neuroendocrine and CRPC-like cells in PCa may be resistant to ARSIs, which could promote the progression of prostate cancer to CRPC, another study also pointed out that neuroendocrine cells with low AR expression have higher proliferation and invasion potential in PCa (Cheng et al. 2022; Su et al. 2022).