Pan et al. (Pan et al. 2024) combined scRNA-seq and multiple techniques to elucidate the characteristic genes (ACTA2, ADAMTS2, ASPN, CDH11, COL1A1, COL1A2, COL3A1, COL5A1, CTSK, POSTN, RAB31, SFRP2, SPARC, THBS2, VCAN) of CAFs in PCa, also demonstrating that CAFs are associated with PCa progression, higher GS scores and CRPC. The gene discussed is COL5A1; the disease is posterior cortical atrophy.