Pan et al. (Pan et al. 2024) combined scRNA-seq and multiple techniques to elucidate the characteristic genes (ACTA2, ADAMTS2, ASPN, CDH11, COL1A1, COL1A2, COL3A1, COL5A1, CTSK, POSTN, RAB31, SFRP2, SPARC, THBS2, VCAN) of CAFs in PCa, also demonstrating that CAFs are associated with PCa progression, higher GS scores and CRPC. Here, ACTA2 is linked to posterior cortical atrophy.