Wen et al. (Wen et al. 2023) analyzed the scRNA-seq data of PCa and found that HOPX, LY6E, THBS1, LDHA, CRISPLD2, FOXC1, SAMD4A, NR4A1, MYC and UBE2S were all involved in the occurrence of PCa. This evidence concerns the gene CRISPLD2 and posterior cortical atrophy.