Another study also indicated that CRISP3 is a key gene associated with desmin expression in bone metastatic prostate cancer (BMPCa), which promotes PCa proliferation and metastasis through the advancement of epithelial-mesenchymal transition (EMT), and that CRISP3 could serve as a therapeutic target to inhibit PCa progression (Zhang et al. 2023a, b). The gene discussed is DES; the disease is posterior cortical atrophy.